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Article

Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid.

Molecular endocrinology (Baltimore, Md.) - 1 Aug 2006

Kusakabe Takashi, Kawaguchi Akio, Hoshi Nobuo, Kawaguchi Rumi, Hoshi Sayuri, Kimura Shioko

Abstract excerpt

Thyroid-specific enhancer-binding protein (T/ebp)/Nkx2.1-null mouse thyroids degenerate by embryonic day (E) 12-13 through apoptosis whereas T/ebp/Nkx2.1-heterogyzgous mice exhibit hypothyroidism with elevated TSH levels. To understand the role of T/ebp/Nkx2.1 in the adult thyroid, a thyroid follicular cell-specific conditional knockout (KO) mouse line, T/ebp(fl/fl);TPO-Cre, was established that expresses Cre...

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Identifiers

PMID: 16601074
DOI: 10.1210/me.2005-0327
PMCID: PMC2588428

Genes

TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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