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Article

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

6 Feb 2014

Abstract excerpt

The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinocytes causes sebaceous gland enlargement and seborrhea in mice due to upregulation of the growth factor epigen, which we identified as a novel Nrf2 target. This was accompanied...

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PMID: 24503019
DOI: 10.1002/emmm.201303281

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