Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice.

PloS one - 17 Nov 2009

Kimura Hiroaki J, Chen Cindy Y, Tzou Shey-Cherng, Rocchi Roberto, Landek-Salgado Melissa A, Suzuki Koichi, Kimura Miho, Rose Noel R, Caturegli Patrizio

Abstract excerpt

BACKGROUND: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. METHODOLOGY/PRINCIPAL FIN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma, Oxyphilic
Share to Cell Nucleus
Share to Hashimoto Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothyroidism

Share to Immune System

Share to Interferon-gamma

Share to Proteasome Endopeptidase Complex

Share to Thyroid Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 19924240
DOI: 10.1371/journal.pone.0007857
PMCID: PMC2773418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19924240-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice.PMID 19924240Read ↗

Mitophagy defects exacerbate inflammation and aberrant proliferation in lymphocytic thyroiditisSemantic proximity Read ↗

Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases.Semantic proximity Read ↗

Immune-parenchymal multicellular niches are shared across distinct thyroid autoimmune diseasesSemantic proximity Read ↗

Decoding Hashimoto’s Thyroiditis: Key Genes and Pathways in Inflammation and PyroptosisSemantic proximity Read ↗

Transcriptome Network Analysis Reveals Aging-Related Mitochondrial and Proteasomal Dysfunction and Immune Activation in Human ThyroidSemantic proximity Read ↗

Identification and Experimental Validation of Genes Associated with Programmed Cell Death in Dendritic Cells of the Thyroid Tissue in Hashimoto's ThyroiditisSemantic proximity Read ↗

Molecular Convergence Between Hashimoto's Thyroiditis and Thyroid MALT Lymphoma: A Scoping Review of Shared Lymphomagenic Mechanisms and Pre-Neoplastic PotentialSemantic proximity Read ↗

Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels.Semantic proximity Read ↗

NF-κB Mediated Thyroid Inflammation and Its Implications for the Risk of Follicular Thyroid Carcinoma: a systematic reviewSemantic proximity Read ↗

Thyroid cancer phenotypes in relation to inflammation and autoimmunity.Semantic proximity Read ↗

Mesenchymal stem cells alleviate autoimmune thyroiditis by modulating macrophage phenotypes and through influencing the STING pathway.Semantic proximity Read ↗

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.