Article
Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.
Frontiers of medicine - 1 Jun 2020
Yang Jun, Wang Lianqing, Huang Yingzhi, Liu Keqiang, Lu Chaoxia, Si Nuo, Wang Rongrong, Liu Yaping, Zhang Xue
Abstract excerpt
Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in γ-secretase component genes. We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI. In this study, we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice. We determined that this mutant...
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