Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin.

Abstract excerpt

Strong inhibition of NF-κB signaling in the epidermis results in spontaneous skin inflammation in mice and men. As there is evidence for linkage between polymorphisms within the NF-κB signaling pathway and human inflammatory skin phenotypes, we asked whether partial functional inhibition of NF-κB signaling in epidermal keratinocytes can modulate clinically relevant skin inflammation. We therefore mutated rela...

Topics

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• Dermatitis, Allergic Contact
• Epidermis
• In Vitro Techniques
• Keratinocytes
• NF-kappa B