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Article

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2005

Li Mei, Messaddeq Nadia, Teletin Marius, Pasquali Jean-Louis, Metzger Daniel, Chambon Pierre

Abstract excerpt

To investigate the role of retinoid X receptors (RXRs) in epidermal homeostasis, we generated RXRalphabeta(ep-/-) somatic mutants in which both RXRalpha and RXRbeta are selectively ablated in epidermal keratinocytes of adult mice. These mice develop a chronic dermatitis mimicking that observed in atopic dermatitis (AD) patients. In addition, they exhibit immunological abnormalities including elevated serum levels...

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Identifiers

PMID: 16199515
DOI: 10.1073/pnas.0507385102
PMCID: PMC1253602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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