Article
Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.
The Journal of investigative dermatology - 1 Jan 2011
Liang Yanhua, Seymour Rosemarie E, Sundberg John P
Abstract excerpt
The NF-κB pathway performs pivotal roles in diverse physiological processes such as immunity, inflammation, proliferation, and apoptosis. NF-κB is kept inactive in the cytoplasm through association with inhibitors (IκB), and translocates to the nucleus to activate its target genes after the IκBs are phosphorylated and degraded. Here, we demonstrate that loss of function of SHANK-associated RH domain interacting...
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