Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.

doi:10.1073/pnas.1107577108

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Article

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2011

Zak Daniel E, Schmitz Frank, Gold Elizabeth S, Diercks Alan H, Peschon Jacques J, Valvo Joe S, Niemistö Antti, Podolsky Irina, Fallen Shannon G, Suen Rosa, Stolyar Tetyana, Johnson Carrie D, Kennedy Kathleen A, Hamilton M Kristina, Siggs Owen M, Beutler Bruce, Aderem Alan

Abstract excerpt

Precise control of the innate immune response is essential to ensure host defense against infection while avoiding inflammatory disease. Systems-level analyses of Toll-like receptor (TLR)-stimulated macrophages suggested that SHANK-associated RH domain-interacting protein (SHARPIN) might play a role in the TLR pathway. This hypothesis was supported by the observation that macrophages derived from chronic...

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Identifiers

PMID: 21709223
DOI: 10.1073/pnas.1107577108
PMCID: PMC3136315

Genes

SHARPIN
TLR2

Provenance

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