Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment and characterization of a new immortalized human oral keratinocyte (HOK) cell line harboring various TP53 mutations.

Oral oncology - 1 Jan 2026

Zhao Mei, Liu Zhiyi, Kawabe Mutsuki, Osman Abdullah A, Frederick Mitchell J, Myers Jeffrey N

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is characterized by frequentTP53mutations, which include gain-of-function (GOF) variants that drive tumor progression and chemoresistance. While genomic evidence across multiple specimens ranging from oral pre-malignant lesions (OPL) through invasive and metastatic HNSCC indicates that TP53 loss or mutation occurs relatively early in HNSCC carcinogenesis, it has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gain of Function Mutation
Share to TP53 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Mutation

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41319400
DOI: 10.1016/j.oraloncology.2025.107799
PMCID: PMC13098770

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment and characterization of a new immortalized human oral keratinocyte (HOK) cell line harboring various TP53 mutations.PMID 41319400Read ↗

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer.Semantic proximity Read ↗

TP53 mutations in head and neck cancer.Semantic proximity Read ↗

Unravelling the heterogeneity of oral squamous cell carcinoma by integrative analysis of single‐cell and bulk transcriptome dataSemantic proximity Read ↗

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapiesSemantic proximity Read ↗

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss.Semantic proximity Read ↗

Targeted sequencing reveals TP53 as a potential diagnostic biomarker in the post-treatment surveillance of head and neck cancer.Semantic proximity Read ↗

Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.Semantic proximity Read ↗

TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.Semantic proximity Read ↗

Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities.Semantic proximity Read ↗

Genomic Enrichment and Functional Impact of TP53 and CYLD Alterations in Recurrent and Metastatic HPV-Associated Head and Neck Cancer.Semantic proximity Read ↗

Molecular characterisation in tongue squamous cell carcinoma reveals key variants potentially linked to clinical outcomes.Semantic proximity Read ↗

TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.