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A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance

17 Jul 2020

Abstract excerpt

The antibiotic actinonin kills malaria parasites ( Plasmodium falciparum ) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity against bacteria. However, Amberg Johnson et al. (2017) identified the metalloprotease Tg FtsH1 as the target of actinonin in the related parasite Toxoplasma...

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PMID: 32678064
DOI: 10.7554/elife.58629

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