Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.

doi:10.1128/AAC.00582-07

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.

Antimicrobial agents and chemotherapy - 1 Nov 2007

Nagamune Kisaburo, Moreno Silvia N J, Sibley L David

Abstract excerpt

Artemisinin is a plant sesquiterpene lactone that has become an important drug for combating malaria, especially in regions where resistance to other drugs is widespread. While the mechanism of action is debated, artemisinin has been reported to inhibit the sarcoplasmic endoplasmic reticulum Ca(2+) ATPase (SERCA) in the malaria parasite. Artemisinin is also effective against Toxoplasma in vitro and in vivo,...

Topics

Animals
Antiprotozoal Agents
Artemisinins
Blotting, Western
Calcium
Calcium-Transporting ATPases
Drug Resistance
Homeostasis
Mutagenesis
Mutation
Sarcoplasmic Reticulum
Toxoplasma

Source

Open in PubMed Open full text

Identifiers

PMID: 17698618
DOI: 10.1128/AAC.00582-07
PMCID: PMC2151471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics