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Article

Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

Biochemistry - 20 May 2008

Colgrave Michelle L, Kotze Andrew C, Huang Yen-Hua, O'Grady John, Simonsen Shane M, Craik David J

Abstract excerpt

The cyclotides are a novel family of backbone-cyclized cystine-knot containing peptides from plants that have been shown to possess insecticidal activity against Helicoverpa larvae, an important pest of corn and cotton. In the current study, we investigated the in vitro effects of the cyclotides on the viability of egg, larval, and adult life stages of two species of economically important gastrointestinal...

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Identifiers

PMID: 18426225
DOI: 10.1021/bi800223y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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