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Article

New twists in anti-malarial drug resistance.

Cell chemical biology - 16 Oct 2025

Cubillán-Marín José, Gilberger Tim W

Abstract excerpt

In this issue of Cell Chemical Biology, Bopp et al.1 discover that malaria parasite resistance to halofuginone is mediated by mutations in PfApiAT2, an amino acid transporter, rather than halofuginone's target prolyl-tRNA synthetase. This rapid and distinctive resistance mechanism highlights amino acid transport as a promising avenue for drug discovery.

Read the complete abstract on PubMed

Topics

Antimalarials
Drug Resistance
Plasmodium falciparum
Humans
Piperidines
Quinazolinones
Mutation
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protozoan Proteins

Malaria

Amino Acyl-tRNA Synthetases

Source

Identifiers

PMID: 41106355
DOI: 10.1016/j.chembiol.2025.09.009

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