Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Forward Genetic Screening Identifies a Small Molecule That Blocks Toxoplasma gondii Growth by Inhibiting Both Host- and Parasite-Encoded Kinases

12 Jun 2014

Abstract excerpt

The simultaneous targeting of host and pathogen processes represents an untapped approach for the treatment of intracellular infections. Hypoxia-inducible factor-1 (HIF-1) is a host cell transcription factor that is activated by and required for the growth of the intracellular protozoan parasite Toxoplasma gondii at physiological oxygen levels. Parasite activation of HIF-1 is blocked by inhibiting the family of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Parasitic Infections and Diagnostics
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24945800
DOI: 10.1371/journal.ppat.1004180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Forward Genetic Screening Identifies a Small Molecule That Blocks Toxoplasma gondii Growth by Inhibiting Both Host- and Parasite-Encoded KinasesPMID 24945800Read ↗

A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondiiSemantic proximity Read ↗

Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1Semantic proximity Read ↗

New antibacterials for the treatment of toxoplasmosis; a patent reviewSemantic proximity Read ↗

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.Semantic proximity Read ↗

TgIF2K-B is an eIF2α kinase in <i>Toxoplasma gondii</i> that responds to oxidative stress and optimizes pathogenicitySemantic proximity Read ↗

Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1Semantic proximity Read ↗

The class XIV myosin of <i>Toxoplasma gondii</i> , TgMyoA, is druggable in an animal model of infectionSemantic proximity Read ↗

Forward Genetics in Toxoplasma gondii Reveals a Family of Rhoptry Kinases That Mediates PathogenesisSemantic proximity Read ↗

Review of Experimental Compounds Demonstrating Anti-Toxoplasma ActivitySemantic proximity Read ↗

Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.Semantic proximity Read ↗

siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in Toxoplasma gondii-Infected CellsSemantic proximity Read ↗

High throughput screening of <i>Toxoplasma gondii</i> clones by PCR after limitation cloningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.