Article

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

2017-02-15

Abstract excerpt

The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import and organelle inheritance during parasite replication. These critical biogenesis pathways present untapped opportuni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13d40764-63c4-51b0-a0f3-0f6820621d90
DOI: 10.1101/108910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogensDOI 10.1101/108910Read

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens.Semantic proximity Read

A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistanceSemantic proximity Read

Evidence that disruption of apicoplast protein import in malaria parasites evades delayed-death growth inhibitionSemantic proximity Read

Targeting the apicoplast in malariaSemantic proximity Read

Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box MoleculesSemantic proximity Read

The Plastid-Like Organelle of Apicomplexan Parasites as Drug TargetSemantic proximity Read

A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria.Semantic proximity Read

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activitySemantic proximity Read

Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in <i>Toxoplasma gondii</i>Semantic proximity Read

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.Semantic proximity Read

A mutagenesis screen for essential plastid biogenesis genes in human malaria parasitesSemantic proximity Read

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparumSemantic proximity Read