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Article

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens.

eLife - 18 Aug 2017

Amberg-Johnson Katherine, Hari Sanjay B, Ganesan Suresh M, Lorenzi Hernan A, Sauer Robert T, Niles Jacquin C, Yeh Ellen

Abstract excerpt

The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import and organelle inheritance during parasite replication. These critical biogenesis pathways present untapped...

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Identifiers

PMID: 28826494
DOI: 10.7554/eLife.29865
PMCID: PMC5576918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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