Article
Evolution of drug-resistant and virulent small colonies in phenotypically diverse populations of the human fungal pathogen Candida glabrata.
Proceedings. Biological sciences - 29 Jul 2020
Duxbury Sarah J N, Bates Steven, Beardmore Robert E, Gudelj Ivana
Abstract excerpt
Antimicrobial resistance frequently carries a fitness cost to a pathogen, measured as a reduction in growth rate compared to the sensitive wild-type, in the absence of antibiotics. Existing empirical evidence points to the following relationship between cost of resistance and virulence. If a resistant pathogen suffers a fitness cost in terms of reduced growth rate it commonly has lower virulence compared to the...
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