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Article

A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata.

FEMS yeast research - 9 Jan 2024

Arastehfar Amir, Daneshnia Farnaz, Hovhannisyan Hrant, Cabrera Nathaly, Ilkit Macit, Desai Jigar V, Gabaldón Toni, Shor Erika, Perlin David S

Abstract excerpt

Drug-resistant microbes typically carry mutations in genes involved in critical cellular functions and may therefore be less fit under drug-free conditions than susceptible strains. Candida glabrata is a prevalent opportunistic yeast pathogen with a high rate of fluconazole resistance (FLZR), echinocandin resistance (ECR), and multidrug resistance (MDR) relative to other Candida. However, the fitness of C....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39545363
DOI: 10.1093/femsyr/foae035
PMCID: PMC11631428

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