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Article

Fitness trade-offs restrict the evolution of resistance to amphotericin B.

PLoS biology - 1 Oct 2013

Vincent Benjamin Matteson, Lancaster Alex Kelvin, Scherz-Shouval Ruth, Whitesell Luke, Lindquist Susan

Abstract excerpt

The evolution of drug resistance in microbial pathogens provides a paradigm for investigating evolutionary dynamics with important consequences for human health. Candida albicans, the leading fungal pathogen of humans, rapidly evolves resistance to two major antifungal classes, the triazoles and echinocandins. In contrast, resistance to the third major antifungal used in the clinic, amphotericin B (AmB), remains...

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Identifiers

PMID: 24204207
DOI: 10.1371/journal.pbio.1001692
PMCID: PMC3812114

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Source receipt: pubmed, retrieved 7 Sept 2026.

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