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Article

A Somatic Mutation in HIF-2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Jan 2026

Gao Feiqiong, Feng Xudong, Yao Qigu, Ji Weiqin, Zhang Xinying, Pan Qiaoling, Zhu Bin, Yu Jiong, Cao Hongcui, Zhang Xianfeng

Abstract excerpt

Hypoxia-inducible factor 2α (HIF-2α) plays a critical role in metabolic regulation. Previously, our team identified a novel mutation (c.C2473T, p.R825W) within the C-terminal transactivation domain of HIF-2α, which was associated with the pathogenesis of non-alcoholic fatty liver disease. The present study aimed to investigate the relationship between this mutation and disorders of glucose and lipid metabolism,...

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Share to Basic Helix-Loop-Helix Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41467846
DOI: 10.1096/fj.202502296RR
PMCID: PMC12752453

Genes

CD36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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