Article
Genomic architecture of human neuroanatomical diversity.
Molecular psychiatry - 1 Aug 2015
Toro R, Poline J-B, Huguet G, Loth E, Frouin V, Banaschewski T, Barker G J, Bokde A, Büchel C, Carvalho F M, Conrod P, Fauth-Bühler M, Flor H, Gallinat J, Garavan H, Gowland P, Heinz A, Ittermann B, Lawrence C, Lemaître H, Mann K, Nees F, Paus T, Pausova Z, Rietschel M, Robbins T, Smolka M N, Ströhle A, Schumann G, Bourgeron T
Abstract excerpt
Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of...
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