Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-ε4 Carriers.

Cerebral cortex (New York, N.Y. : 1991) - 3 Nov 2020

Fortel Igor, Korthauer Laura E, Morrissey Zachery, Zhan Liang, Ajilore Olusola, Wolfson Ouri, Driscoll Ira, Schonfeld Dan, Leow Alex

Abstract excerpt

Synaptic dysfunction is hypothesized to be one of the earliest brain changes in Alzheimer's disease, leading to "hyperexcitability" in neuronal circuits. In this study, we evaluated a novel hyperexcitation indicator (HI) for each brain region using a hybrid resting-state structural connectome to probe connectome-level excitation-inhibition balance in cognitively intact middle-aged apolipoprotein E (APOE) ε4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connectome

Share to Genotype

Share to Magnetic Resonance Imaging

Share to Neural Pathways

Source

Open in PubMed Open full text

Identifiers

PMID: 32662517
DOI: 10.1093/cercor/bhaa190
PMCID: PMC7609923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-ε4 Carriers.PMID 32662517Read ↗

Disrupted excitation-inhibition balance in cognitively normal individuals at risk of Alzheimer’s diseaseSemantic proximity Read ↗

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.Semantic proximity Read ↗

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease PathogenesisSemantic proximity Read ↗

Unveiling paths to Alzheimer’s disease: excitation-inhibition ratio shapes hierarchical dynamicsSemantic proximity Read ↗

Evidence against altered excitatory/inhibitory balance in the posteromedial cortex of young adult APOE E4 carriers: a resting state <sup>1</sup> H-MRS studySemantic proximity Read ↗

Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?Semantic proximity Read ↗

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathologySemantic proximity Read ↗

Cognitive reserve and gamma entrainment-related network changes in prodromal Alzheimer’s diseaseSemantic proximity Read ↗

Structural and Synaptic Dysregulation Drives Network Vulnerability in APOE4 Human Neuronal NetworksSemantic proximity Read ↗

Estradiol and memory circuitry in the postmenopause: Modification by APOE4Semantic proximity Read ↗

Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.Semantic proximity Read ↗

The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain FunctionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.