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Article

G604S-HERG mutation in LQT2 leads to autophagy via the UPR-related pathway.

Journal of biosciences - 1 Jan 2020

Zhao Yun, Ma Shuting, Cao Miaomiao, Sun Chaofeng

Abstract excerpt

Congenital long QT syndrome (LQTS) is a heart channel disease associated with fatal ventricular arrhythmias or cardiac arrest. Human ether-a-go-go-related gene (HERG) mutation is one of the main causes in type 2 LQTS since it may lead to abundant immature HERG channel protein accumulate in the endoplasmic reticulum (ER). In our study, we have successfully constructed the G604S-HERG mutation in HEK293 cells and...

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PMID: 32661217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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