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Article

Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression.

Clinical and experimental pharmacology & physiology - 1 Sept 2016

Huo Jianhua, Zhang Aifeng, Guo Xueyan, Qiang Hua, Liu Ping, Bai Ling, Ma Aiqun

Abstract excerpt

Mutations in human ether-a-go-go-related gene (hERG) can lead to type 2 long-QT syndrome (LQT2). The authors previously identified the hERG mutation G604S results in a loss of function and obviously decreased current amplitude and impaired channel protein trafficking when co-expressed with WT-hERG. The present study further investigates the biological and electrophysiological consequences of pharmacologic...

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Identifiers

PMID: 27199074
DOI: 10.1111/1440-1681.12593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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