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Article

Altered autophagic flux in GNE mutant cells of Indian origin: Potential drug target for GNE myopathy.

Experimental cell research - 1 Jul 2024

Oswalia Jyoti, Singh Shagun, Gautam Vaishali, Arya Ranjana

Abstract excerpt

Autophagy phenomenon in the cell maintains proteostasis balance by eliminating damaged organelles and protein aggregates. Imbalance in autophagic flux may cause accumulation of protein aggregates in various neurodegenerative disorders. Regulation of autophagy by either calcium or chaperone play a key role in the removal of protein aggregates from the cell. The neuromuscular rare genetic disorder, GNE Myopathy, is...

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PMID: 38852763
DOI: 10.1016/j.yexcr.2024.114118

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