Article
Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.
Cell biochemistry and biophysics - 1 Jan 2005
Keller Steven H, Platoshyn Oleksandr, Yuan Jason X-J
Abstract excerpt
Hereditary long QT syndrome is a fatal arrhythmia associated with gene mutations in potassium and sodium channels that are expressed in ventricle. By employing heterologous expression and making comparisons to cells expressing wild-type human-ether-a-go-go-related protein (HERG), a potassium channel that contributes to I(Kr) current in ventricular cardiomyocytes, we demonstrate activation of an elevated...
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