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Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2020

Gu Ning, Dai Wei, Liu Hongliang, Ge Jie, Luo Sheng, Cho Eunyoung, Amos Christopher I, Lee Jeffrey E, Li Xin, Nan Hongmei, Yuan Hua, Wei Qingyi

Abstract excerpt

BACKGROUND: Cutaneous melanoma (CM) is the most lethal type of skin cancers. Nicotinamide adenine dinucleotide phosphate (NADPH) plays an important role in anabolic reactions and tumorigenesis, but many genes are involved in the NADPH system. METHODS: We used 10,912 single-nucleotide polymorphisms (SNPs) (2018 genotyped and 8894 imputed) in 134 NADPH-related genes from a genome-wide association study (GWAS) of...

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Aldehyde-Lyases
Cohort Studies
Follow-Up Studies
Melanoma
Metabolic Networks and Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Analysis

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PMID: 32659474
DOI: 10.1016/j.ejca.2020.04.049
PMCID: PMC7540967

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