Article
Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death.
JNCI cancer spectrum - 31 Aug 2023
Gibbs David Corley, Thomas Nancy E, Kanetsky Peter A, Luo Li, Busam Klaus J, Cust Anne E, Anton-Culver Hoda, Gallagher Richard P, Zanetti Roberto, Rosso Stefano, Sacchetto Lidia, Edmiston Sharon N, Conway Kathleen, Ollila David W, Begg Colin B, Berwick Marianne, Ward Sarah V, Orlow Irene
Abstract excerpt
BACKGROUND: It is unclear whether genetic variants affecting vitamin D metabolism are associated with melanoma prognosis. Two functional missense variants in the vitamin D-binding protein gene (GC), rs7041 and rs4588, determine 3 common haplotypes, Gc1s, Gc1f, and Gc2, of which Gc1f may be associated with decreased all-cause death among melanoma patients based on results of a prior study, but the association of...
Read the complete abstract on PubMed