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Update on the structure and function of Candida albicans drug efflux protein, Cdr1

31 Oct 2024

Abstract excerpt

• Candida albicans Cdr1 is an important drug efflux pump. • This protein is also an attractive drug target. • Structural organisation and amino acid sequence are important for Cdr1 activity. • Additional aspects to consider is Cdr1 localisation and phosphorylation. Candida albicans is an important human pathogenic yeast, that can become resistant to commonly used antifungal agents, such as azoles. One mechanism...

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PMID: 39486613
DOI: 10.1016/j.fgb.2024.103938

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