Article
Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.
Biochimica et biophysica acta - 1 Nov 2016
Nim Shweta, Lobato Lucia Gonzalez, Moreno Alexis, Chaptal Vincent, Rawal Manpreet Kaur, Falson Pierre, Prasad Rajendra
Abstract excerpt
The ABC (ATP-Binding Cassette) transporter Cdr1 (Candida drug resistance 1) protein (Cdr1p) of Candida albicans, shows promiscuity towards the substrate it exports and plays a major role in antifungal resistance. It has two transmembrane domains (TMDs) comprising of six transmembrane helices (TMH) that envisage and confer the substrate specificity and two nucleotide binding domains (NBDs), interconnected by...
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