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Article

Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation.

The Journal of biological chemistry - 10 Nov 2006

Xu Lin, Renaud Ludivine, Müller Joachim G, Baicu Catalin F, Bonnema D Dirk, Zhou Hongming, Kappler Christiana S, Kubalak Steven W, Zile Michael R, Conway Simon J, Menick Donald R

Abstract excerpt

The Na+-Ca2+ exchanger (NCX1) is up-regulated in hypertrophy and is often found up-regulated in end-stage heart failure. Studies have shown that the change in its expression contributes to contractile dysfunction. We have previously shown that the 1831-bp Ncx1 H1 (1831Ncx1) promoter directs cardiac-specific expression of the exchanger in both development and in the adult, and is sufficient for the up-regulation...

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Identifiers

PMID: 16966329
DOI: 10.1074/jbc.M607446200
PMCID: PMC3096005

Genes

GATA4
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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