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Article

Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish

13 Jan 2015

Abstract excerpt

BACKGROUND: Genetic studies of cardiomyopathy and heart failure have limited throughput in mammalian models. Adult zebrafish have been recently pursued as a vertebrate model with higher throughput, but genetic conservation must be tested. METHODS AND RESULTS: We conducted transcriptome analysis of zebrafish heart and searched for fish homologues of 51 known human dilated cardiomyopathy-associated genes. We also...

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PMID: 25583992
DOI: 10.1161/circgenetics.114.000702

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