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Article

Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005

Langenbacher Adam D, Dong Yuan, Shu Xiaodong, Choi Jayoung, Nicoll Debora A, Goldhaber Joshua I, Philipson Kenneth D, Chen Jau-Nian

Abstract excerpt

Cardiac fibrillation, a form of cardiac arrhythmia, is the most common cause of embolic stroke and death associated with heart failure. The molecular mechanisms underlying cardiac fibrillation are largely unknown. Here we report a zebrafish model for cardiac fibrillation. The hearts of zebrafish tremblor (tre) mutants exhibit chaotic movements and fail to develop synchronized contractions. Calcium imaging showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16314583
DOI: 10.1073/pnas.0502679102
PMCID: PMC1308881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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