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Article

Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression.

Proceedings of the National Academy of Sciences of the United States of America - 25 Mar 2008

Sultana Naznin, Nag Kakon, Hoshijima Kazuyuki, Laird Dale W, Kawakami Atsushi, Hirose Shigehisa

Abstract excerpt

Heart development is a precisely coordinated process of cellular proliferation, migration, differentiation, and integrated morphogenetic interactions, and therefore it is highly susceptible to developmental anomalies such as the congenital heart disease (CHD). One of the major causes of CHD has been shown to be the mutations in key cardiac transcription factors, including nkx2.5. Here, we report the analysis of...

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Share to Connexins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Homeobox Protein Nkx-2.5

Share to Morphogenesis

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Source

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Identifiers

PMID: 18337497
DOI: 10.1073/pnas.0708451105
PMCID: PMC2290751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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