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Article

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.

Cancer research - 1 Aug 2015

Izquierdo-Garcia Jose L, Viswanath Pavithra, Eriksson Pia, Cai Larry, Radoul Marina, Chaumeil Myriam M, Blough Michael, Luchman H Artee, Weiss Samuel, Cairncross J Gregory, Phillips Joanna J, Pieper Russell O, Ronen Sabrina M

Abstract excerpt

Mutant isocitrate dehydrogenase 1 (IDH1) catalyzes the production of 2-hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and pyruvate dehydrogenase (PDH) activity have been shown to be affected in U87 glioblastoma cells or normal human astrocyte (NHA) cells expressing mutant IDH1, as compared with cells expressing wild-type IDH1. In this study, we show how these phenomena...

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Identifiers

PMID: 26045167
DOI: 10.1158/0008-5472.CAN-15-0840
PMCID: PMC4526330

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.PMID 26045167Read ↗

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