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In vivo Metabolic Profiles as Determined by 31P and short TE 1H MR-Spectroscopy : No Difference Between Patients with IDH Wildtype and IDH Mutant Gliomas.

Clinical neuroradiology - 1 Mar 2019

Wenger Katharina J, Hattingen Elke, Franz Kea, Steinbach Joachim, Bähr Oliver, Pilatus Ulrich

Abstract excerpt

PURPOSE: Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas. We investigated whether these changes can be found in vivo using 1H-decoupled 31P magnetic resonance spectroscopic imaging (MRSI) with 3D chemical shift imaging (CSI) at 3 T in patients with low and high-grade gliomas....

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PMID: 28983683
DOI: 10.1007/s00062-017-0630-8

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