Article
Association between altered metabolism and genetic mutations in human glioma.
Cancer reports (Hoboken, N.J.) - 1 May 2023
Pearl Hannah, Fleischer Candace C
Abstract excerpt
BACKGROUND: Molecular markers for classification of gliomas include isocitrate dehydrogenase (IDH) mutations and codeletion of chromosomal arms 1p and 19q (1p/19q). While mutations in IDH enzymes result in the well-characterized production of oncometabolite 2-hydroxyglutarate, dysregulation of other metabolites in IDH tumors is less characterized. Similarly, the effects of 1p/19q codeletion on cellular metabolism...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
