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Article

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters.

Oncotarget - 7 Jun 2016

Viswanath Pavithra, Najac Chloe, Izquierdo-Garcia Jose L, Pankov Aleksandr, Hong Chibo, Eriksson Pia, Costello Joseph F, Pieper Russell O, Ronen Sabrina M

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) are characteristic of low-grade gliomas. We recently showed that mutant IDH1 cells reprogram cellular metabolism by down-regulating pyruvate dehydrogenase (PDH) activity. Reduced pyruvate metabolism via PDH could lead to increased pyruvate conversion to lactate. The goal of this study was therefore to investigate the impact of the IDH1 mutation on the...

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Source

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Identifiers

PMID: 27144334
DOI: 10.18632/oncotarget.9006
PMCID: PMC5085201

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters.PMID 27144334Read ↗

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.Semantic proximity Read ↗

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Molecular Imaging of Metabolic Reprograming in Mutant IDH CellsSemantic proximity Read ↗

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Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.Semantic proximity Read ↗

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Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 MutationSemantic proximity Read ↗

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