Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomisation

Abstract excerpt

<h4>Objective</h4> Polymyalgia rheumatica (PMR) is an age-related inflammatory disease of unknown cause. We aimed to identify potentially modifiable risk factors and therapeutic targets for preventing or treating PMR. <h4>Methods</h4> We meta-analysed genetic association data from 8,156 cases of PMR (defined using diagnostic codes and self-report) and 416,495 controls of European ancestry from the UK Biobank and F...

Topics

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• Biomarkers
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Inflammation
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Risk Factors
• Smoking

Identifiers and source

Literature Corpus work

eeca02ab-1009-5eaa-8fb1-71d5e4a9e69b

DOI

10.1101/2024.04.21.24306135