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Article

Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomization.

Rheumatology (Oxford, England) - 1 May 2025

Zhao Sizheng Steven, Mackie Sarah L, Larsson Susanna C, Burgess Stephen, Yuan Shuai

Abstract excerpt

OBJECTIVE: PMR is an age-related inflammatory disease of unknown cause. We aimed to identify potentially modifiable risk factors and therapeutic targets for preventing or treating PMR. METHODS: We meta-analysed genetic association data from 8156 cases of PMR (defined using diagnostic codes and self-report) and 416 495 controls of European ancestry from the UK Biobank and FinnGen. We then performed Mendelian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38788669
DOI: 10.1093/rheumatology/keae308
PMCID: PMC7616751

Genes

CCDC88B
CXCL6
IL1R1
NEK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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