Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.

doi:10.1016/j.ebiom.2024.104991

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Article

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.

EBioMedicine - 1 Feb 2024

Yarmolinsky James, Robinson Jamie W, Mariosa Daniela, Karhunen Ville, Huang Jian, Dimou Niki, Murphy Neil, Burrows Kimberley, Bouras Emmanouil, Smith-Byrne Karl, Lewis Sarah J, Galesloot Tessel E, Kiemeney Lambertus A, Vermeulen Sita, Martin Paul, Albanes Demetrius, Hou Lifang, Newcomb Polly A, White Emily, Wolk Alicja, Wu Anna H, Le Marchand Loïc, Phipps Amanda I, Buchanan Daniel D, Zhao Sizheng Steven, Gill Dipender, Chanock Stephen J, Purdue Mark P, Davey Smith George, Brennan Paul, Herzig Karl-Heinz, Järvelin Marjo-Riitta, Amos Chris I, Hung Rayjean J, Dehghan Abbas, Johansson Mattias, Gunter Marc J, Tsilidis Kostas K, Martin Richard M

Abstract excerpt

BACKGROUND: Tumour-promoting inflammation is a "hallmark" of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. METHODS: We meta-analysed 6 genome-wide association studies of circulating inflammatory...

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Identifiers

PMID: 38301482
DOI: 10.1016/j.ebiom.2024.104991
PMCID: PMC10844944

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