Article

Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts

2023-11-03

Abstract excerpt

Chronic inflammation is a hallmark of ageing and age-related disease states. The effectiveness of inflammatory proteins such as C-reactive protein (CRP) in assessing long-term inflammation is hindered by their phasic nature. DNA methylation (DNAm) signatures of CRP may act as more reliable markers of chronic inflammation. We show that inter-individual differences in DNAm capture 50% of the variance in circulating...

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Literature Corpus work: 0d7fa793-ecd7-50e9-b42f-25bebd6e264d
DOI: 10.1101/2023.11.02.23298000

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