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Article

Voltage-dependent modulation of TRPA1 currents by diphenhydramine.

Cell calcium - 1 Sept 2020

Shen Xianfeng, Wang Qiaochu, Lin Yakang, Sreekrishna Koti, Jian Zhiyuan, Zhu Michael X, Tian Jinbin

Abstract excerpt

Diphenhydramine (DPH) has been broadly used to treat allergy. When used as a topical medicine, DPH temporarily relieves itching and pain. Although transient receptor potential type A1 (TRPA1) channel is known to play roles in both acute and chronic itch and pain, whether DPH affects the activities of TRPA1 remains unclear. Using whole-cell patch clamp recordings, we demonstrated that DPH modulates the...

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Identifiers

PMID: 32634675
DOI: 10.1016/j.ceca.2020.102245
PMCID: PMC7959105

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