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Article

The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

The Journal of biological chemistry - 21 Nov 2008

Wang Yuanyuan Y, Chang Rui B, Waters Hang N, McKemy David D, Liman Emily R

Abstract excerpt

The transient receptor potential A1 (TRPA1) channel is the molecular target for environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil. Extracellular Ca(2+) is a key regulator of TRPA1 activity, both potentiating and subsequently inactivating it. In this report, we provide evidence that the effect of extracellular Ca(2+) on these processes is indirect and can be entirely attributed...

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Identifiers

PMID: 18775987
DOI: 10.1074/jbc.M803568200
PMCID: PMC2583289

Genes

TRPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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