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Article

Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

19 Jul 2016

Abstract excerpt

The transient receptor potential channels (TRPs) respond to chemical irritants and temperature. TRPV1 responds to the itch-inducing endogenous signal histamine, and TRPA1 responds to the itch-inducing chemical chloroquine. We showed that, in sensory neurons, TRPV4 is important for both chloroquine- and histamine-induced itch and that TRPV1 has a role in chloroquine-induced itch. Chloroquine-induced scratching was...

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PMID: 27436359
DOI: 10.1126/scisignal.aaf1047

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