Article
Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate.
Molecular pharmacology - 1 Sept 2013
Gees Maarten, Alpizar Yeranddy A, Boonen Brett, Sanchez Alicia, Everaerts Wouter, Segal Andrei, Xue Fenqin, Janssens Annelies, Owsianik Grzegorz, Nilius Bernd, Voets Thomas, Talavera Karel
Abstract excerpt
Allyl isothiocyanate (AITC; aka, mustard oil) is a powerful irritant produced by Brassica plants as a defensive trait against herbivores and confers pungency to mustard and wasabi. AITC is widely used experimentally as an inducer of acute pain and neurogenic inflammation, which are largely mediated by the activation of nociceptive cation channels transient receptor potential ankyrin 1 and transient receptor...
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