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Article

Ultra-mutated colorectal cancer patients with POLE driver mutations exhibit distinct clinical patterns.

Cancer medicine - 1 Jan 2021

Hu Hanguang, Cai Wen, Wu Dehao, Hu Wangxiong, Dong Wang Li, Mao Jianshan, Zheng Shu, Ge Weiting

Abstract excerpt

POLE mutations, which lead to an ultramutated phenotype in colorectal cancer (CRC), have been reported as a promising marker in immunotherapy. We performed sequencing of CRC cases in Zhejiang University (ZJU) and extracted obtainable data from recently published results, including The Cancer Genome Atlas (TCGA), Japanese studies and clinical trials, to present clinical patterns of POLE driver-mutated CRC and...

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Identifiers

PMID: 33125191
DOI: 10.1002/cam4.3579
PMCID: PMC7826451

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