Article
China special issue on gastrointestinal tumors-NTRK fusion in a large real-world population and clinical utility of circulating tumor DNA genotyping to guide TRK inhibitor treatment.
International journal of cancer - 1 Dec 2023
Qi Changsong, Zhou Ting, Bai Yuezong, Chen Hui, Yuan Jiajia, Zhao Feilong, Liu Chang, Ma Mingyang, Bei Ting, Chen Shiqing, Zhao Xiaochen, Chen Chunzhu, Shen Lin
Abstract excerpt
Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers and targets of TRK inhibitors in solid tumors. Little is known about NTRK fusion in Chinese patients with pan-cancer. Our study investigated the prevalence and genomic features of NTRK1/2/3 gene fusions in 67 883 Chinese patients with pan-cancer using next-generation sequencing (NGS) data and circulating tumor DNA (ctDNA) NGS...
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