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Article

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing.

Journal of translational medicine - 17 Oct 2021

Wang Jing, Li Ruiyu, Li Junjie, Yi Yuting, Liu Xiaoding, Chen Jingci, Zhang Hui, Lu Junliang, Li Cami, Wu Huanwen, Liang Zhiyong

Abstract excerpt

BACKGROUND: Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1me+) and wild-type BRAF and RAS. In this study, dMMR CRCs were screened for oncogene fusions using sequential DNA and RNA next generation sequencing (NGS). RESULTS: Comprehensive analysis of fusion variants, genetic profiles and...

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Identifiers

PMID: 34657620
DOI: 10.1186/s12967-021-03108-6
PMCID: PMC8522100

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