Article

Comprehensive Analysis of Oncogenic Fusions in Mismatch Repair Deficient Colorectal Carcinomas by Sequential DNA and RNA Next Generation Sequencing

2021-06-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with <italic>MLH1</italic> hypermethylation (<italic>MLH1</italic><sup>me+</sup>) and wild-type <italic>BRAF</italic> and <italic>RAS</italic>. In this study, dMMR CRCs were screened for oncogene fusions using sequential DNA a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 32305f8e-5caf-54b3-af8a-bd00093eb087
DOI: 10.21203/rs.3.rs-544833/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of Oncogenic Fusions in Mismatch Repair Deficient Colorectal Carcinomas by Sequential DNA and RNA Next Generation SequencingDOI 10.21203/rs.3.rs-544833/v1Read

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing.Semantic proximity Read

Targeted next generation sequencing of MLH1 ‐deficient, MLH1 promoter hypermethylated, and BRAF / RAS ‐wild‐type colorectal adenocarcinomas is effective in detecting tumors with actionable oncogenic gene fusionsSemantic proximity Read

Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers.Semantic proximity Read

Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas.Semantic proximity Read

Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase FusionsSemantic proximity Read

Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase FusionsSemantic proximity Read

Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal CancersSemantic proximity Read

Molecular Lineages of Sporadic Mismatch Repair-Deficient Colorectal Cancer.Semantic proximity Read

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.Semantic proximity Read

Mutation profile and molecular heterogeneity in mismatch repair deficient endometrial carcinomaSemantic proximity Read

Clinic-pathological characteristics of MMR protein, KRAS-NRAS-BRAF gene mutation, HER-2 and PD-L1 status in 3822 Chinese colorectal cancer patientsSemantic proximity Read

Patterns of germline and somatic mutations in 16 genes associated with mismatch repair function or containing tandem repeat sequences.Semantic proximity Read